Yes- generally : With along imaging studies and increased psa, biopsy is typically recommended to confirm diagnosis.
Answered 9/10/2013
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Options for: Therapy depend on gleason score, extra-capsular exxtesnsion, and symptoms, so the biopsy aids and secures a foundation. Some consider adjacent nodes "locally advanced". Sadly, some present with distant bony disease, and biopsy is always suggested along with psa to monitor progress of treatment approaches.
Answered 5/2/2013
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