Are there any natural dieretic or over-the-counter drugs/supplements to help with depression? can low testosterone lead to depression?

Yes on both...: There are otc drugs to help w/ depression (st. John's wart, sam-e, omega fatty acids), but none are fda approved for treatment of a mood disorder. Low testosterone can lead to depression. After age 30, men start seeing a gradual reduction of their hormone levels. Mention both to your primary care physician at the next appointment.