Stg 4 liver mets, breast cancer. on 4/15 got- 650, gpt 350, bilirbn 18. now got- 390, gpt 190, bilirbn 24. on herceptin, carboplatin, linezolid, cipro (ciprofloxacin). why bilirbn increasing while gpt/ got improving?

The SGOT/SGPT tests: Now usually called ast/alt are related to liver cell injury. Bilirubin elevation, however, reflects cholestatic processes, so it can go up when the others go down. Alkaline phosphatase also probably very high?

Liver mets and liver: Injury and inflammation could be worsening despite an improvement in lftss with bile duct obstruction and elevated alkaline phophatase.Follow up with your oncologist.God bless you! http://www.Healthline.Com/health/liver-metastases http://m.Cancer.Org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/herbsvitaminsandminerals/index?Sitearea=eto.

Tumor growth: I'm being very honest here. In my experience, this is a sign of tumor growth causing obstruction of your bile ducts. Your bilirubin is too high for you to safely get most types of chemo. The tumor may be obstructing the main bile duct, and sometimes that can be stented. But this is a time to ask your doc for an honest prognosis. Warm thoughts to you.