I was diagnosed with anal carcinoma in situ twice what are the chances that it will reoccure?

Unfortunately High: Anal carcinoma in situ is a rare pre-cancerous condition that often will recur. It may be associated with HIV and is usually directly caused by hpv. Sometimes close observation by anal "mapping" every 3-4 months is enough with small operations to remove any new lesions as needed. In other instances, treatment with imiquimod, laser therapy or radiation therapy might be recommended.