How many hours do i need to wait to take a 10mg flexeril after taking a 0.5 xanax?

These can be taken in any order as they work on different systems and have no interaction between them. So take them if you need them but remember that Xanax is addictive.

Xanax and Flexeril together have a drug interaction that can cause moderate CNS depression. Xanax has a half-life elimination approx 12.5 hours. Three half-lives is considered reasonable, so after 37 hours. Always monitor symptoms and side effects with new medications

https://www.drugs.com/drug-interactions/flexeril-with-xanax-758-386-133-54.html Xanax concentration peaks in blood is after 2 hours , Flexeril peaks in about 4 hours so would take them about 4 hours apart.

Please discuss this with your Primary Care Physician or Orthopedic Surgeon if this is the result of managing pain after an injury. For long-term pain please go to a pain management clinic for further diagnosis.