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A member asked:
I am about to start methotrexate for my rheumatoid arthritis and have had genital herpes in the past. how common is the outbreak and how severe is it?
A doctor has provided 1 answer
It is not a contraindication for using methotrexate with history of HSV-2 related genital herpes. There is not any reliable study regarding the severity of HSV 2 reactivation with methotrexate use that I have known of. One study recommends NOT checking HSV titers before initiating treatment with methotrexate. Good luck with your treatment.
Answered 7/15/2023
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