A member asked:

Why do some antipsychotics lower dopamine and inadvertently cause depression?

Q: why do some antipsychotics lower dopamine and inadvertently cause depression?

: Antipsychotics, especially the first-generation or typical antipsychotics, block dopamine receptors in the brain. Dopamine is a neurotransmitter which has a significant role in the pathophysiology of depression. These interactions explains depression could be one of the side effects of antipsychotics.

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Dr. Hiep Le answered

Specializes in Nephrology and Dialysis

Antipsychotics, especially the first-generation or typical antipsychotics, block dopamine receptors in the brain. Dopamine is a neurotransmitter which has a significant role in the pathophysiology of depression. These interactions explains depression could be one of the side effects of antipsychotics.

Answered 5/17/2022

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A member asked:

Why do some antipsychotics lower dopamine and inadvertently cause depression?

A doctor has provided 1 answer

Dr. Hiep Le answered

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