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A 30-year-old male asked:

What's the purpose of giving pregabalin with nortriptyline combination in rls? isn't just pregabalin itself effective for rls symptoms, why doctors prefer giving an anti- depressant medicine combination in rls when its supposed to be taken for years?

1 doctor answer1 doctor weighed in
Dr. Bennett Machanic
Neurology 52 years experience
Have no insight as to "why doctors prefer", but will repeat fact that successful RLS treatment may involve dopamine agonist or even pregabalin. Have not found tricyclic antidepressants to be of value in RLS. Recommend you go to paid portion of HT and obtain virtual consult so a more thorough perspective can be explored.

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Last updated Jul 21, 2021

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