HealthTap Online Primary Care Doctors Accepting New Patients
Book a video visit
HealthTap
Telehealth
A member asked:

My neurologist prescribed zanaflex 4mg to take at night as a migraine preventative and im also prescribed lunesta 2mg for insomnia. can i take these two together?

A doctor has provided 1 answer

Disagree with combo: Each independently is relatively safe, but together would have additive drowsiness, sedation, and affect normal sleep stages. You would likely feel hung over in the morning. In my opinion, there are far better ways of preventing migraine headaches. Consider getting a second opinion.

Dr Rhoads agreed

Answered 4/8/2021

0 views

Thank

Related Questions

A member asked:

Can I take melatonin or Benadryl daily for severe insomnia? Whats the highest dose of melatonin I can take. Im exhausted. Lack of sleep is a migraine trigger.

A doctor has provided 1 answer

A member asked:

I use these very sparingly but I had bad insomnia last night and want to take a Lunesta (eszopiclone) my dr gave me. I had a glass of wine 4 hours ago. Is it ok?

2 doctors weighed in across 2 answers

A member asked:

I just took 4 excedrine migraine in the span of hours, along with 2 tizanidine HCl 4 mg; 2 amitriptyline 25mg, and two l-trypto have i overdosed or need to be concerend

2 doctors weighed in across 2 answers

A member asked:

Is it safe to take 4mg of lunesta (eszopiclone) in conjunction with 4mg of periactin to help me sleep. I suffer from ptsd, chronic insomnia, adhd.

A doctor has provided 1 answer

A member asked:

Is it ok to take trazodone 100 mg and lunesta (eszopiclone) 3mg nightly for insomnia? neither one by themselves relieves the insomnia. Thank you

4 doctors weighed in across 2 answers

Sponsored Content
HealthTap Medical Group does not endorse products or services. Sponsored content revenues support our mission to make health information free and accessible to all.Learn more

People also searched for:

Can I safely take 2mg zanaflex with one 220mg aleve and 25mg of phenergan (promethazine) for migraine not responding to my imitrex?
I'm 8 w pregnant and started spotting 2 d ago a brown color. My neurologist has me taking a baby asprin to prevent another aphasic migraine. Is it ok?
Can zanaflex be used to help with pain symptoms at the onset of a migraine headache?
Can I take lunesta (eszopiclone) together with seroquel for insomnia??
Psych gave me lunesta (eszopiclone) to take with citalopram at night since my anxiety insomnia is BAD. Normally i take cital in the AM and it doesn't make me tired so will I STILL have insomnia at night? need sleep

Telemedicine

Primary Care
Manage Your Conditions
Women's Health
Children's Health
Men's Health
Senior Health
Wellness, Prevention & Lifestyle
Sexual Health
Mental & Behavioral Health
Travel Medicine
Urgent Care
Ask your question
Didn't find what you're looking for?

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.

Ask your question

More of what we treat

Allergies
Antibiotics
Asthma
High Blood Pressure
Prescriptions
Type 2 Diabetes
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.
HealthTap
HIPAA logo
HIPAASecure
Soc 2 Type 2 logo
SOC 2 Type 2Certified
JCAHO Accredited
JCAHOAccredited
Member App

Download HealthTap

Video visit and message your doctor

Member App QR Code
Play Store Member LinkApp Store Member Link

Questions?

+1 (888) 828-0841support@healthtap.com
LinkedInTwitter
HomeTermsPrivacyCookiesDMCAHealth TopicsDoctors DirectoryDoctor Q&A by Specialty
Copyright 2026 HealthTap, Inc.