That amount of drop in B12 would be of concern that you are not absorbing B12 well from your diet, or that you need more in your daily diet. The Pepcid, being an acid blocker, could affect the absorption of B12 yes. Most people can overcome that by taking a larger dose, perhaps 1000 micrograms per day, of oral B12, & do not need injections
Answered 4/1/2021
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