I take seroquel 50mg is it safe to take clobenzaprine?

Two meds: There is a risk of serotonergic syndrome if you take both together which can cause increased temperature, delirium and other unwelcome side effects requiring ER care. The risk is small. Assuming that you are taking seroquel for sleep, ask your doctor if it is ok to stop the seroquel while you take the muscle relaxant, which is meant for short term use only.