Can skipping your meds (antidepressants) for 2 days cause your anxiety spike again?

Yes: If you have medications that are meant to be taken daily (such as an SSRI) - that could lead to increased anxiety and other symptoms.

Agree with Dr. F: In addition to taking your medication regularly, exercise daily as exercise is therapeutic for depression and anxiety. Have a healthy diet, exercise 30 minutes/day, drink plenty of water, have safe sex, no tobacco alcohol weed or street drugs. For nutrition: http://www.choosemyplate.gov/. Wish you good health!