A member asked:

Been suppressing testerone (male to eunuch) for 4 yrs with androcur n no estrogen but very recently started estradiol gel 1mg n patches n felt calmer and better overall. does estradiol increase serotonin n calms when t is low? male. 37. diabetic.

A doctor has provided 1 answer
Dr. Yvette Kratzberg answered

Specializes in Pediatrics

Monitor closely: Using an antiandrogen blocks the actions of male sex hormones (androgens)/reduces the amount of male sex hormones produced by the body. It should not be used in patients with uncontrolled diabetes. It can also cause depression. Estrogen, may relieve depressive symptoms, but has the risk of blood clots. It increases serotonin and can elevate mood. A Dr should be monitoring you closely

Answered 6/18/2020

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