Herxheimer reaction?: Depends in part on reason for penicillin. The most common need for PCN by injection is syphilis. If so, you may be having a Jarisch-Herxheimer reaction (named for the docs who first described it). Billions of dying syphilis bacteria release toxins. It means the PCN is working and you’ll be cured. It will clear up in 1-2 days. Ibuprofen can help. Contact doc or clinic if uncertain.
Answered 3/2/2020
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