A member asked:

Safe combo? 12.5mg zoloft, 0.25 klonopin, 5mg flexeril, 3mg melatonin. all around the same time at night.

A doctor has provided 1 answer

Not a good idea: The combination of flexeril and zoloft increase risk of serotonin syndrome-confusion, increased HR and BPm fever, sweating and seizures, really not a good combo in general, zoloft ,klonipin and flexeril will all have enhanced sedation, and confusion SE when used together. Melatonin can combine with out issue-definately talking with your prescriber.

Answered 7/30/2019



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