Safe combo? 12.5mg zoloft, 0.25 klonopin, 5mg flexeril, 3mg melatonin. all around the same time at night.

Not a good idea: The combination of flexeril and zoloft increase risk of serotonin syndrome-confusion, increased HR and BPm fever, sweating and seizures, really not a good combo in general, zoloft ,klonipin and flexeril will all have enhanced sedation, and confusion SE when used together. Melatonin can combine with out issue-definately talking with your prescriber.