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A 24-year-old female asked:

Ana, speckled @ 1:320, esr 30. all antibody ena tests are negative. symptoms point to lupus. can it be lupus w/o typical antibodies or complements?

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Dr. Alonso Morales Medina
Dr. Alonso Morales Medinaanswered
Specializes in Medicina Interna
No. : Current guidelines indicate that you need four positive criteria, of which at least one clinical criteria and one immunologic criteria (positive antibodies) to diagnose Lupus. So, short answer: no, you can't have lupus without one of the immunologic criteria. Immunologic criteria include: ANA, Anti-DNA, Anti-Sm, antiphospholipid Ab, low complement (C3, C4) and direct boom's test.
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Last updated Apr 24, 2019

Found in:

Antibody›Lupus erythematosus

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