Can asthma be relegated to one lobe or lung? meaning, that significant trapping/tightness is found in one area. ironically, also a sight of collapse.

Wouldn't think so : Asthma can/does produce scarring in some patients & one lung may be more involved than the other. However, asthma on the molecular level is based on a genetically derived imbalance between the reactive molecules that trigger spasm/episodes and the relaxation chemicals that calm them down. This effects all the reactive tissues within both lungs.

Yes: Since the anatomy of different parts of the lungs are not identical, one lobe may be more inflamed than the other but it will be highly unlikely to have part of lung entirely normal. Pneumothorax has been known in severe asthma attack due to severe air trapping. Obviously the weakest part gives out first. But this is a rare complication.

Agree with Dr. F: Asthma affect both lungs about equally. If symptoms are limited to one area, it suggest a local pathology. It would be prudent to consult a pulmonologist.

Start with an exam: You can start by an exam with your primary care doctor. They can either diagnose you, order testing or Xrays and if necessary refer you to the proper specialist.

Atelectasis: There can be areas of abnormal distribution of air in the branches of the airway tree. Some areas may be more affected than others. Please have a pulmonary function test and follow up imaging as indicated.