If i put my two 500 mg pills of azythromycin in water and let them dissolve, will they still be affective?

Yes: If you took all the water with the dissolved antibiotic it should be effective. Wish you good health! - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex. Get HPV vaccine

Effective, but...: ...why would you do it? It will be very bitter and unpleasant and quite difficult to swallow. There is a version of azithromycin intended for people with problems taking pills, 1 gram (equal to two 500 mg doses) of flavored powder intended to be taken as a single dose mixed with water. It's also a little ibtter, but a lot less than the pills. Ask your doctor or pharmacist.