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A member asked:
Between allegra and desloratadine, which drug has less blood-brain barrier permeability and is less anticholinergic?
A doctor has provided 1 answer
Allegra: Fexofenadine and loratadine, allegra and claritin, respectively, are the least sedating of all anti-histamines according to a recent NIH review. All anti-histamines cross the blood brain barrier to some extent. The real issue is sedation and allegra and claritin appear to win the context. They are also less anticholinergic than many others.
Answered 6/12/2017
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