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Lehigh Acres, FL
A 29-year-old male asked:

Why is it that baclofen interacts with clonazepam?took baclofen and felt more anxious. currently tapering off of 0.5mg clonazepam. gaba interaction?

2 doctor answers4 doctors weighed in
Dr. Edward Workman
Specializes in Pain Management
Side effect: What you're describing is likely a side effect and not an interaction. Klonopin should block anxiety symptoms, but, although baclofen is typically sedative, it causes anxiety in some people. This is a paradoxical side effect and not an interaction. Think twice before you taper off klonopin (tapering really isn't necessary due to the long 1/2 life); it's a good muscle relaxer. Stop the baclofen.
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Dr. Al Hegab
Dr. Al Hegabanswered
Allergy and Immunology 42 years experience
CNS depression: and increased seizure activity, if epileptic, may be the consequence of the combination.I'm not sure why you take the clonazepam, but it is wise to avoid the combination if possible, till done with the baclofen. Clonazepam is a controlled drug, and better confer with your provider regarding dose change. GABA effects: this is how the clonazepam acts, and adding baclofen might increase such activity
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Jun 11, 2017


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