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Northbrook, IL
A male asked:

On vyvanse 40mg and just had 1st zoloft 25mg last night. had insomnia and diarrhea last night. should i take it pm again or should i try morning?

1 doctor answer1 doctor weighed in
Dr. Edward Workman
Specializes in Pain Management
Morning dosing .: Zoloft is a serotonin increasing agent, via the blockade of transporters in the nerve nets that remove it from the synapse. Also it does this to a lesser extent with dopamine, thus increasing that neurotransmitter. The GI tract is heavily innervated by serotonin and many people develop diarrhea or other GI symptoms from it. Also taking it at night is a bad idea due to increased dopamine.
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Last updated May 26, 2017


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