Morning dosing .: Zoloft is a serotonin increasing agent, via the blockade of transporters in the nerve nets that remove it from the synapse. Also it does this to a lesser extent with dopamine, thus increasing that neurotransmitter. The GI tract is heavily innervated by serotonin and many people develop diarrhea or other GI symptoms from it. Also taking it at night is a bad idea due to increased dopamine.
Answered 5/26/2017
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