Can crestor (rosuvastatin) be crushed?

Difficult to answer: Though the manufacturer does not specifically warn against this, "film coated" tablets are usually designed that way to minimize any stomach upset that may be caused by the drug itself (this should not be confused with "enteric or delayed release coatings).

Yes and no: Crestor’s maker suggests it should be taken whole and not be crushed, chewed, or broken. There is no reason that it cannot necessarily be crushed, aside from the coating possibly masking the drug’s medicinal taste, but do be aware upon crushing the tablet, some of the coating pieces could remain, kind of how like if you crushed M&M’s, you’d see the difference between chocolate and candy coating.