Can depression occur as result of trying to manage chronic condition(lupus)even after it's in remission with meds.i exercise but am always fatigued?

Yes, definitely: This is a very common condition. And it's something that can be helped. Don't simply seek an anti-depressant however. A complicated condition like Lupus requires careful mgmt of Rx(s) and a good Health Psychologist w/ experience in chronic condition self-mgmt will be helpful but best if they can coordinate w/ your medical Dr. Be hopeful - this is often very successful. Best!