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A male asked:

I seem to have a very high tolerance to lidocaine. i have never done drugs. what could cause this?

3 doctor answers5 doctors weighed in
Dr. Louis Delcampo
Specializes in Anesthesiology
Rapid metab?: Some people are rapid metabolizers of amide type local anesthetics like lidocaine. A simple genetic test (buccal swab) would give you the answer. People do not usually develop a tolerance to lidocaine. There are many other choices for local anesthesia. The Ester class of LA could also be used. Like any other medicine it is based on weak science and trial and error. The Art of Medicine!
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Philip Miller
A Verified Doctoranswered
Family Medicine 48 years experience
Strength of dose/typ: Lidocaine ( Xylocaine ) comes as both 1% and 2% Other options would be a stronger local anesthesia such as mepivicaine or pontocaine.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Kathy Robinson
Family Medicine 33 years experience
Metabolism: We do not know exactly why, but some people metabolize substances much faster than others. It seems to have to do with the genetics of the enzyme systems in the liver in most cases.
Created for people with ongoing healthcare needs but benefits everyone.

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Last updated Oct 19, 2017
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