It is...: a progressive damaging effects to capillaries in/near glomeruli leading to local inflammatory change and scarring with subsequent malfunction in filtering the blood for reabsorbing useful blood components and excreting the unwanted metabolic wastes, which exact causes are still unclear, though, long-term high blood sugar is the culprit. This is usually a slow process of >5-15 years.
Answered 6/13/2017
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