Get Virtual Care
For Businesses
About Us
A member asked:
I am taking mtx for my sle (10mg/wk). my ast alt numbers have been rising (outside of range) since i started. at what point is it too high?
2 doctors weighed in across 2 answers
Your Dr decides: The decision on whether to continue Methotrexate in the face of some evidence of liver injury must be based on your rheumatologist's judgement. Remember that a few drinks a day can shoot the ast and alt up as well. Lupus is a rough disease, and the saying in lab medicine (my area) is "treat the person, not the number." be strong, stay proactive & best wishes.
Answered 6/28/2014
5.2k views
Lower the dose: Any elevation is too high. The dose needs to be reduced. Over the long term, Methotrexate can cause serious liver issues.
Answered 6/28/2014
5.2k views
Related Questions
A member asked:
Labs show AST 67 & ALT 101. Everything else was normal. Are those numbers that high? I am 38, no drugs or alcohol.
A doctor has provided 1 answer
A member asked:
How long does it take for cirrhosis to happen drinking with high ALT & ast? No hep c, 27yo male, drinking 7 years, all other numbers normal
A doctor has provided 1 answer
A member asked:
My liver count is AST 34 (normal), ALT 54 (high), IFCC 92 (normal), G-GT 48 (normal). Are those numbers worrisome?
A doctor has provided 1 answer
People also searched for:
What would cause low total bili? Other lft's are normal although ALT & AST are rising.On methotrexate (sarocidosis) im sure will be lowering mtx soon
Lupus patient- last round of tests show abnormally high bilirubin levels and abnormally low AST and ALT. What would cause this and what would it mean?
Arthritis, lupus ruled out.Joint pain, migraines, kidney stones, recent sinus & Eustachian tube problems, + ANA, elevated CRP & ALP, ALT, AST. Ideas?
Hx of crohns, kidney failure, enlarged liver-14cm, skin issues, ^ in alt,ast,crp, extreme fatigue for 10yrs and unexplained fevers. maybe lupus?
My liver function tests are normal but my ast/alt ratio is high is that a concern? ast 22 u/l alt is 6 u/l. All other numbers well within range.
Didn't find what you're looking for?
90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.
Ask your questionMore of what we treat
Download HealthTap
Video visit and message your doctor
