My wife,40,type ab negative blood while mine is type b positive, is pregnant again for 25 weeks. how to prevent and treat fetal hemolytic reaction.

ABO hemolysis: Hemolysis in newborns due to ABO incompatibility is not preventable, but is manageable under the care of an experienced pediatrician or neonatologist. For this reason, newborns from mothers with type O blood type or who are Rh- will be screened closely for this condition, as early recognition and intervention is key to successful recovery.

Rhogam: Your situation describes Rh incompatibility. You are positive and she is negative. She should have received the Rhogam injection immediately after her previous pregnancies or even before miscarriages. If any of your previous children already had hemolytic reactions, that means your current child is at higher risk and will need to be monitored closely. He or she may require exchange transfusions.