A member asked:

Alt 61. ast and rest of lft's normal. is this concerning? taking lipitor, (atorvastatin) possible cause? pcp not concerned. should he be? should be?

A doctor has provided 1 answer

No, see below: “Statins increase alanine aminotransferase (ALT) concentrations (one of the enzymes from the liver) in 10% of recipients, and this increase can exceed more than three times the upper limit of normal in 1% of patients. Despite a lack of evidence that statins cause liver disease, many physicians are reluctant to start statins in patients with an out-of-range ALT value. Most patients with high ALT will have fatty liver or non-alcoholic steatohepatitis (NASH), because 20% or more of patients in developed countries have these conditions (i.e., a fifth of people in developed countries have fatty liver or NASH, and on occasion many, but not all, have abnormal ALTs)

Answered 11/28/2017

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