A member asked:

How long does one orlistat pill last?

2 doctors weighed in across 2 answers

1-2 Hours: The half life is 1-2 hours. That means that the medicine only stays in your intestines for a few hours. In 2 hours, only 60mg is still effective if you took a 120mg pill. That is why it must be taken with food.

Answered 9/14/2016

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Dr. Alvin Lin answered

Half-life = 1-2hrs: https://online.epocrates.com/noframe/showpage.do?method=drugs&monographid=2062&activesectionid=7 lists half-life of orlistat (sold as xenical & alli) as 1-2hrs. Most drugs are theoretically out of your system after 5 half-lives. In this case, you're looking at 5-10hrs.

Answered 7/8/2016

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