Is it possible to have lupus and a negative ana? muscle, pain, swillwn nodes, rash, brain fog on and off for 8 yrs negative for hiv, lymes, cancers.

Yes: Yes, there is a term called "seronegative spondyloarthropathies" and all it really means is a group of disorders that act like inflamnatory arthritic conditions, but there blood tests are negative. Many patients in this group will ultimately "convert" years later when their blood tests turn positive. This includes people who are later diagnosed with RA and Lupus, among others.