How is metformin and gliclazide different even though they lower blood sugar?

Diabetes medications: Metformin (http://www.drugs.com/metformin.html) is 1st drug considered for new diagnoses diabetes type 2. We generally describe it as making you more sensitive to insulin. As long as you have good kidney function, metformin is fine. Gliclazide is a sulfonylurea that convinces your pancreas to produce more insulin. Don't forget to eat healthy foods & exercise regularly.