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A member asked:
What is the risk of taking grapefruit and gabapentin? i take 100mg every 6 hours and ate half a grapefruit today. feeling lousy. help.
2 doctors weighed in across 2 answers
Grapefruit/gabapenti: If you're curious about the mechanism of action, I found a few quotes that may help: none Like gabapentin, pregabalin binds to the α2δ (alpha2delta) subunit of the voltage-dependent calcium channel in the central nervous system. Pregabalin decreases the release of neurotransmitters such as glutamate, noradrenaline, and substance P (Australian Medicines Handbook). Pregabalin increases neuronal GABA
Answered 6/26/2016
1.5k views
No interaction: There are no known drug-food interactions between gabapentin and grapefruit. It is safe to eat/drink grapefruit while on gabapentin. Grapefruit can interact with other medications (e. g., birth control, blood pressure medications) so you may want to assess other medications or causes for possible interactions.
Answered 6/26/2016
1.5k views
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