Can drinking 3 to 4 glasses of wine every other night while on wellbutrin (bupropion) xl 150mg make wellbutrin (bupropion) less effective on helping depression and how much?

Likely: You may need to look at your alcohol abuse and get help with substance abuse.

Alcohol depresses: Alcohol, while possibly briefly making you happier, is a depressant with long term use. How much will it take to sabotage the effects of antidepressant medication is hard to say, as it varies by individuals. However, the amount you are talking about is not healthy, whether depressed or not. Discuss this with your treating doc and your therapist. Fastest response to medication & therapy? No booze

Hasn't your doctor: advised medically against use of alcohol in this scenario? Can't give you a statistic about how certain amounts of alcohol can increase depression by certain amounts. Bottom line is that it looks like a # of doctors are tell you that this is not safe. It sounds like you have a problem with alcohol.