A member asked:

What's the difference in taking accutane 2 times a day(2x40mg), breakfast and dinner instead of just taking once a day at dinner ?

A doctor has provided 1 answer

Below: Accutane has a fairly long half-life so it shouldn’t hurt if patients fit the dosage schedule to their lifestyle. (Drugs with long half-lives do not need to be taken in split doses to maintain adequate blood levels). Taking large single doses can cause indigestion (hence warning on label to take with or after food), so if you want to take it as a single dose with a meal, fine. If it causes indigestion, split into two doses.

Answered 2/7/2016

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