The germs: It takes a while to kill the germs.They have been there for at least 12 hrs (or more) before you started meds and had plenty of time to create havoc/injure tissue and elaborate chemical factors that make you tired.You can also have mono at the same time and it wouldn't be obvious unless tested for. Give it a few days and check back in with doc if you don't start feeling better.
Answered 12/30/2016
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