Can you take spironolactone + lipitor (atorvastatin) ? spironolactone will increase the level or effect of lipitor (atorvastatin) by p-glycoprotein (mdr1) efflux transporter. ?

Yes: Although there is an interaction, if you are taking up to 40 mg of Lipitor (atorvastatin), (atorvastatin) you should be fine particularly if you are not having any liver or muscle toxicity. Muscle aches, elevation in AST and ALT are typical toxicities of elevated Lipitor (atorvastatin) levels.

Take together: Two common drug information references fail to support this information. One describes a small, more theoretical interaction that may result in an increase in spironolactone activity (but not atorvastatin), but these two medications are commonly used together without adverse effect.