Prilosec otc box says to use for 14 days, then not use again for 4 months. repeat. most people take it everyday though. is the "box cycle" effective?

It can be: It can be, for very mild symptoms. For more persistent symptoms of reflux, a 6-week course of everyday use often results in prolonged relief that can last for months or longer afterwards. Everyday use without end is reserved for severe cases that don't resolve with initial treatment. You're correct that most people do not use this medication correctly and don't get great results accordingly.