A member asked:

Is it safe to take 4mg zofran same day as 20mg lexapro (escitalopram)? only take the zofran when i have a really bad ibs flare.

2 doctors weighed in across 2 answers

Drug Interaction: The combination of Ondansetron (Zofran) and Escitalopram (Lexapro) can have a serious side effect related to heart rhythm, prolonging one of the phases of heart beat called QT wave or interval. Consider non-drug treatment for IBS. Recent research shows non-drug treatment has more long term efficacy: http://news.vanderbilt.edu/2015/12/psychotherapies-have-long-term-benefit-for-those-suffering-from-

Answered 7/4/2016

1.7k views

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Dr. Keshab Paudel answered

Specializes in Internal Medicine

Okay: It should be okay to take both on the same day.

Answered 1/27/2016

1.7k views

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