It's possible: that your chonic leg pain if neuropathic in nature may feel improved with the combo of an SNRI ilke Effexor plus a low dose olanzapine. The later either works as antidepressant augmentator or a mood stabilizer. Drepresion worsens neuropathic pain , and pain pathways are serotonergic which are modulated by meds like venlafaxine and to a degree also by olanzapine.
Answered 11/30/2015
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