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A 24-year-old male asked:

Can i take melatonin and ambien (zolpidem) (10mg) together? ambien (zolpidem) has lost it's effects and melatonin barely works. whats an overdose level?

1 doctor answer3 doctors weighed in
Dr. Edward Kuhnley
Child Psychiatry 47 years experience
Melatonin and Ambien (zolpidem): do not have significant interaction. Melatonin (OTC) has a role in regulation of the sleep-wake cycle. May dose up to 20 mg/d. Ambien (zolpidem) (prescribed) improves sleep onset; best taken without food. If effect lost then consult prescriber to review your situation and determine best course of action. Review good sleep hygiene (https://sleepfoundation.org/ask-the-expert/sleep-hygiene). Best regards.
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Last updated Jan 1, 2021


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