Can you split a 100mg sumatriptan pill in half and safely take 50mg?

Migraine yes: You can use the Imitrex (sumatriptan) tablet and break half as needed due to intolerance and or side effects. There should not be any difference in effectiveness of the medication per se but it should be realized that your requirement may be more but you can determine that with effectiveness. May repeat dosage after two hours and not to be taken more than two time a day.