Afrin (oxymetazoline) is supposed to: help with decongesting your nostrils so you can breathe while you sleep. So yes the clear liquid coming out must be what the Afrin (oxymetazoline) decongested -- however, if that clear liquid thickens up, or becomes cloudy, and you have more headache/pain noted without using more Afrin (oxymetazoline), you may need to get to a healthcare provider so they can treat you for potential sinus infection.
Answered 10/9/2015
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