What is the best medicine for a cold?

Initial Cold Therapy: Most upper respiratory infections have a viral etiology. The symptoms should be treated with antipyretics (i.e., tylenol), additional rest, and copious fluid (water) consumptions per day. The symptoms usually resolve within 7-10 days. If they do not, or a fever ensues, you should seek the evaluation of your family physician/ internal medicine physician asap.

Tough answer: Very difficult to say but best med is one which makes you feel better...Tylenol (acetaminophen) advil are both effective.

Depends: Depends on your symptoms: fever: tylenol (acetaminophen) or ibuprofen congestion: sudafed, saline cough: dextromethorphan drainage: guaifenesin note that cold and flu medications may contain one or more of these ingredients. Read the label for the "active ingredient" and make sure you are not doubling up on any particular ingredient as this can cause severe side effects. Only take what your need for your symptoms.