Could i safely take minocycline that has been expired for 2 years for acne?

Probably safe: Expired medications are probably safe, in that they won't cause any harm. But, it might not be effective.

Yes and no: It might be safe and something a doc would prescribe, in pills that would have dependable potency. However, at a listed age of 27, why self medicate. Most at that age can get by with a good skin care plan and OTC meds. When this is not working, the choice between topical and oral antibiotic or vitamin A preparations can be difficult.My sis had her most difficulty in her late 20's and early 30's.