A member asked:

What r the side effect of pheniytoin and omeprazol and why can't it be taken together?

2 doctors weighed in across 2 answers
Dr. Georgia Latham answered

Specializes in Family Medicine

Omeprazole: is only one of a total of 1123 drugs known to interact with phenytoin. Anyone taking phenytoin must be very careful about taking any other medications without their doctor and/or pharmacist begin aware. Omeprazole can cause increased blood levels of phenytoin and may result in drowsiness, visual problems, changes in behavior, nausea, or poor muscle coordination.

Answered 8/15/2015

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Dr. Paul Grin answered

Specializes in Pain Management

Drug Interaction: Omeprazole inhibit phenytoin metabolism (CYP2C) and can induce phenytoin liver toxicity. Phenytoin S. E.:ataxia, gingival hyperplasia. Omeprazole S. E.: fast heartbeat, nausea and confusion. Always speak with your physician before taking any medication.

Answered 8/21/2015

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