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A 42-year-old male asked:

is metformin sr 1000mg once daily is better or metformin 500mg twice daily is better for fbs158 n pbs192?

2 doctor answers2 doctors weighed in
Dr. Alvin Lin
Geriatrics 30 years experience
Neither: The better version is that which you can afford and take regularly. Once daily versions are typically more expensive but if you can't afford it, why worry? Twice daily are more troublesome but more affordable. If cost isn't an issue, get the once daily. Both will help control your sugars. Better yet, pay closer attention to your eating habits. And exercise regularly.
Dr. David Sneid
Endocrinology 41 years experience
Neither: The most effective dose of metformin is 1000 mg twice a day with meals.

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A 36-year-old male asked:

Is it safe to take 5 metformin pills & 5 onglyza (saxagliptin) pills on 1 day and take a break for 5 days while fasting?

2 doctor answers4 doctors weighed in
Dr. Richard Scofield
Diabetology 33 years experience
Absolutely not!: There is no rationale for taking metformin or Onglyza (saxagliptin) in that fashion and taking such large amounts all at once may lead to toxic side-effects.
Dr. William Harris
Family Medicine 33 years experience
The equivalent 5-day Onglyza treatment would be once-weekly Bydureon injections. You get all of the benefits of a daily pill in a weekly shot. There is no equivalent, weekly (more convenient) dosing form of metformin yet -- we're still stuck with the once-daily metformin so far...
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