I took 10mg of propranolol 4 hours ago and i take 25mg of zoloft (sertraline) everyday. is this combination okay? would sleeping after taking the propranolol be okay, or would my heart rate decrease too much?

Zoloft (sertraline) & Propanolol: Unless you are hypersensitive, or have any of those catechol amine (like Epinephrine) dysfunction from any medical condition, it does not seem, under ordinary circumstances, that taking 10 mg of Propanolol while on standing 25 mg Sertraline, even if you go to bed.

Drug interaction: According to Medscape Drug Interactions, Zoloft (sertraline) may affect the metabolism of propranolol, possibly enhancing propranolol's effect. Both sleep and propranolol may decrease your heart rate, but the dose of propranolol you describe is low. Suggest talking to your doctor about use of these medications and any other over the counter drugs or supplements.

Probably yes.: Your medications at at extraordinarily low doses. Unless you are also taking other medications that might interact, or have unusual medical conditions, it is surprising that that would accomplish anything for you; and they certainly don't suggest you need to be concerned about serious side effects.

Review Medical: Do you have any pre - existing medical problems, such as increased or decreased blood pressure ? Do you take any other medications ? In general, the combination of Zoloft (sertraline) and Propranolol are considered to be safe and effective for management of anxiety.

Propranolol: 10mg propranolol is such a low dose for adults that it should not decrease heart rate significantly.