A member asked:

Can gastroparesis caused by high dose ppi's be reversed? and are there any clinical papers on this please. thank you

A doctor has provided 1 answer
Dr. Richard Roberts answered

Specializes in Pediatrics

Possibly: long-term PPI may cause severe vitamin B 12 deficiency which may cause a multitude of muscle disorders. You must get a vitamin B12 blood level immediately if not already done, as neurologic damage may be permanent. Diagnosis is typically based on vitamin B12 blood levels below 120–180 picomol/L (170–250 pg/mL) in adults.how did they prove it was due to the PPI's?

Answered 12/15/2019

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