How often does an antidepressant cause someone to have a seizure as a side effect?

Uncommon: Antidepressants vary in their ability to lower the seizure threshold. The commonly prescribed ones today are safer, far less likely to cause seizures as a side effect than antidepressants used a generation ago. If you have a history of seizures, check with your doctor to see if safe to take an antidepressant. If a seizure occurs, get yourself to the ER immediately.