Can asymptomatic liver disease caused by drug overdose present as mental illness due to toxic buildup?

Yes: Our liver is extremely important to keep our bodies in balance. By filtering and "getting rid" of substances that can harm our bodies, a healthy liver contributes to our overall health. Many patients with renal and liver problems, that are not properly treated or diagnosed, usually experience mental changes (in reasoning, memory, judgment,etc), that if left untreated can become permanent.